Evaluation of the Correlation between CD44, Tumor Prognosis and the 5-Year Survival Rate in Patients with Oral Tongue SCC
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Abstract:
Introduction: 90% of the tumors in the head and neck are squamous-cell carcinomas (HNSCC), which have overall 5- year survival rate between 50% -60%. CD44 has been shown to be associated with the prognosis. Materials and Methods: Biopsy specimens of 51 patients with oral tongue SCC were evaluated by Immunohistochemistry (IHC) for the CD44 antibody. Results: There was no significant correlation between CD44 and survival (P=0.77), age (P=0.4), CD44 and lymph node metastasis (P=0.87), sex (P=0.947), smoking (P=0.287) and tumor size (P=0.813). However, there was significant correlation between smoking and survival. Conclusion: There are widespread discrepancies among the findings in the literature regarding the prognosis of CD44 expression in OCSCC. Our study shows that the expression of CD44 is not a marker of aggressive behavior in oral tongue SCC. Consequently, CD44 cannot be considered as handy tool to establish the tumor behavior, prognosis and 5- year survival rate of these tumors.
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evaluation of the correlation between cd44, tumor prognosis and the 5-year survival rate in patients with oral tongue scc
introduction: 90% of the tumors in the head and neck are squamous-cell carcinomas (hnscc), which have overall 5- year survival rate between 50% -60%. cd44 has been shown to be associated with the prognosis. materials and methods: biopsy specimens of 51 patients with oral tongue scc were evaluated by immunohistochemistry (ihc) for the cd44 antibody. results: there was no significant correlatio...
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Journal title
volume 28 issue 6
pages 407- 411
publication date 2016-11-01
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